I had the pleasure of spending yesterday evening at the Royal Society Summer Exhibition. I’d recommend it to anybody if you want to dip in to what British science is about and what it can do for people. To a geek like me it was fascinating to hear first-hand from young scientists about the things which enthuse them. But it also has some deeper messages, especially for where I think government should be putting its money in the forthcoming spending review.
I learned more about the immune system in a 15 minute discussion with one of the young scientists than I had learned in a whole career working in biology (although I am not an immunologist). This conversation squeezed my intellectual juices to the extent that I felt sad that I couldn’t just give up all the complexity of making science work to develop better public policy and get in to the lab. It’s the laboratory, big-or small-scale, that is the engine house where new ideas emerge. It’s a rewarding experience for anybody to look at the immune system. It leaves me in wonder at the complexity of structure that can emerge from a process of natural selection. The immune system is much more complex than anything that mere humans have managed to engineer.
Perhaps there is nothing more fundamental than the question ‘how did life evolve life?’. The really interesting problem is that for life to exist there needs to be a mechanism that induces self-replication of the molecules that code for proteins. We know that this sits within DNA, but DNA cannot replicate without a ribosome which is a small, high complex, organelle that exists within cells just to perform this function. So, the question then arises, “how did ribosomes come in to existence?” Whoever can answer this question is pretty close to answering the most fundamental question of all – how did we get here?
I also have to put in a strong plug for those exhibits that reflected Defra’s science and that were supported directly or indirectly by Defra’s funding. One wasabout influenza viruses. Many vertebrates (including humans) aresusceptible to infection by flu viruses and many of these viruses are able to infect more than one species. There are perhaps a couple of hundred variants of flu viruses depending on the form of two proteins on the surface of the virus, the ‘H’ and the ‘N’ proteins. Birds seem to be able to host almost all these variants and, thankfully, humans just a few. Some are almost benign in that they only cause very mild disease but others are deadly.
A problem is that different strains of each variant can cause different severity of disease. Knowing all this is vital to allow us to be able to design better control systems including understanding paths of infection and designing vaccines. The Spanish flu pandemic of 1918 killed about 50 million people – more than were killed in the First World War. That was the H1N1 variety. Not to be too melodramatic, there are plausible scenarios where, in today’s world of mass travel (which leads to rapid transfer of viruses around the world) we could all succumb to influenza. We need to be on our guard!
Another fascinating Defra science project concerned the importance of meat. Some who have read my recent blogs will know that I am sceptical about meat as a source of nutrition when farmed through intensive rearing systems. However, what this exhibit shows is that through careful management of farming as a whole system and the use of pasture that cannot be used for direct human consumption, cattle producing beef is one of the most efficient ways of turning this in to food for people.
This is about matching, for example, the variety of grass that is grown to the digestive system of the breed of cattle that are eating that grass to maximise the transfer efficiency of grass to beef. In a sense, this is a very different kind of genetic engineering where one is being clever about matching the properties of the grass with the properties of the cattle. When one then starts to build this around ensuring that soils are sustained, rivers don’t become polluted with effluent and we minimise the amount of gas given off to the atmosphere as methane, ammonia or N2 one is starting to understand that the complexities of a farming system begin to match those of the immune system (see above) – and are just as fascinating!
However, for me, the highlight was the exhibit from Tokamak Energy. I learned that ‘tokamak’ is actually a Russian acronym, because the technology was invented in Russia. However, what excited me was that the company was using current technologies to build their machine – they felt they could do this without having to wait for any new basic discoveries to emerge – and they had a business model that was attracting investment. I wish them every success.
I have not been able to mention all the exhibits I saw all of which have their own wonderful stories to tell. However, I am struck by just how fundamental to the future and successes of humanity are all the examples I have given here. Many other exhibits also fell in to this category. From the fundamentals of how life forms through to the building of a machine that could power our future development, it’s a glorious accolade to British science.